Publications

Publications generated with Glenn Center support

| 2017 | Selected Publications from Previous Years |

2018

  • Huang, Das A, GX, Bonkowski, MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, and Sinclair DA Impairment of an endothelial NAD+-H2S signaling network is a reversible cause of vascular aging. (2018). Cell in press

2017

  • Beach RR, Ricci-Tam C, Brennan CM, Moomau CA, Hsu P-H, Hua B, Silberman RE, Springer M, Amon A. Aneuploidy Causes Non-genetic Individuality. Cell. 2017 Apr 6;169(2):229–242.e21. PMID: 28388408
  • Cha Y, Han MJ, Cha HJ, Zoldan J, Burkart A, Jung JH, Jang Y, Kim CH, Jeong HC, Kim BG, Langer R, Kahn CR, Guarente L, Kim KS (2017). Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis.  Nat Cell Biol. 19(5):445-456. doi: 10.1038/ncb3517. Epub 2017 Apr 24.
  • Dellinger RW, Santos SR, Morris M, Evans M, Alminana D, Guarente L, Marcotulli E (2017). Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. NPJ Aging Mech Dis.;3:17. doi: 10.1038/s41514-017-0016-9.
  • Glorioso C, Pfenning AR, Bennett DA, Sibille E, Kellis M, Guarente L (2017).  Molecular brain aging and APOEε4 are independent and additive risk for Alzheimer’s disease.  In revision.
  • Hayashi H, Cherpokova D, Martinod K, Witsch T, Wong SL, Gallant M, Cifuni SM, Guarente LP, Wagner DD (2017). Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice. PLoS One. 2017 Dec 13;12(12):e0188341.
  • Igarashi M, Guarente L. (2017). NAD+ supplementation rejuvenates aged gut adult stem cells via the SIRT1/mTORC1 axis. In review.
  • Ondracek CR, Frappier V, Ringel AE, Wolberger C, Guarente L (2017). Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment. Cell Rep. 18, 2310-2319. doi: 10.1016/j.celrep.2017.02.031.
  • Santaguida S, Richardson A, Iyer DR, M'Saad O, Zasadil L, Knouse KA, Wong YL, Rhind N, Desai A, Amon A. Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System. Dev Cell. 2017 Jun 19;41(6):638-651.e5.
  • Satoh A, Imai SI, Guarente L (2017). The brain, sirtuins, and ageing. Nat Rev Neurosci. 18(6):362-374. doi: 10.1038/nrn.2017.42.
  • Sheltzer JM, Ko JH, Replogle JM, Habibe Burgos NC, Chung ES, Meehl CM, Sayles NM, Passerini V, Storchova Z, Amon A. Single-chromosome Gains Commonly Function as Tumor Suppressors. Cancer Cell. 2017 Feb 13;31(2):240–255. PMID: 28089890
  • Tang YC, Yuwen H, Wang K, Bruno PM, Bullock K, Deik AA, Santaguida S, Trakala M, Pfau SJ, Zhong N, Huang T, Wang L, Clish CB, Hemann MT, Amon A. (2017). Aneuploid cell survival relies upon sphingolipid homeostasis. Cancer Res. 2017 Aug 3.
  • Wellman AS, Metukuri MR, Kazgan N, Xu X, Xu Q, Ren NSX, Czopik A, Shanahan MT, Kang A, Chen W, Azcarate-Peril MA, Gulati AS, Fargo DC, Guarente L, Li X (2017). Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota. Gastroenterology. 153(3):772-786. doi: 10.1053/j.gastro 2017.05.022. Epub 2017 May 26.
  • Zainabadi K, Liu CJ, Guarente L (2017). SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2. PLoS One. 12(5):e0178520. doi: 10.1371/journal.pone.0178520. 
  • Zainabadi K, Liu CJ, Caldwell ALM, Guarente L (2017). SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis. PLoS One. 12(9):e0185236. doi: 10.1371/journal.pone.0185236.

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  • Igarashi M, Guarente L. (2016). mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction. Cell. 2016 Jul 14;166(2):436-50. doi: 10.1016/j.cell.2016.05.044. Epub 2016 Jun 23.
  • Igarashi M, Guarente L. (2016). The unexpected role of mTORC1 in intestinal stem cells during calorie restriction. Cell Cycle Aug 11:1-2.
  • Knouse, Kristin A., Jie Wu, and Angelika Amon, Assessment of megabase-scale somatic copy number variation using single cell sequencing. Genome Research, 2016 Mar; 26(3): 376–384. doi:  10.1101/gr.198937.115
  • Raja, W.K., Mungenast, A.E., Lin, Y.T., Ko, T., Abdurrob, F., Seo, J., Tsai, LH. Self- Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes (2016). PLoS One. 2016 Sep 13;11(9).
  • Madabhushi, R., Gao, F., Pfenning, A., Pan, L., Yamakawa, S., Seo, S., Rueda, R., Phan, T., Yamakawa, H., Pao, P.C., Stott, R.T., Gjoneska, E., Nott, A., Cho, S., Kellis, M., Tsai, L-H. Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes (2015). Cell 161, 1592–1605.
  • Wilson, R. H. C., Hesketh, E. L. & Coverley, D. The nuclear matrix: Fractionation techniques and analysis (2016). Cold Spring Harb. Protoc. 2016, 5–10.
  • Chalkiadaki A and Guarente L. (2015) The multifaceted functions of sirtuins in cancer. Nat Rev Cancer. 2015 Oct;15(10):608-24.
  • Gjoneska, E., Pfenning,A., Mathys, H., Quon, G., Kundage, A., Tsai, L-H, Kellis, M. Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease (2015). Nature 518, 365–369.
  • Madabhushi, R., Gao, F., Pfenning, A. R., Pan, L., Yamakawa, S., Seo, J., Rueda, R., Phan, T. X., Yamakawa, H., Pao, P. C., Stott, R. T., Gjoneska, E., Nott, A., Cho, S., Kellis, M. & Tsai, L. H. (2015). Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes. Cell 161, 1592-1605 PMID: 26052046
  • Santaguida S, Vasile E, White E, Amon A. Aneuploidy-induced cellular stresses limit autophagic degradation. Genes Dev. 2015 Oct 1;29(19):2010-21.
  • Santaguida S, Amon A. Aneuploidy triggers a TFEB-mediated lysosomal stress response. Autophagy. 2015 Nov;11(12):2383-4. doi: 10.1080/15548627.2015.1110670.
  • Knouse KA, Wu J, Whittaker CA, Amon A. Single cell sequencing reveals low levels of aneuploidy across mammalian tissues. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13409-14.
  • Madabhushi, R., Pan, L. & Tsai, L. H. (2014). DNA damage and its links to neurodegeneration. Neuron 83, 266-282 PMID: 25033177
  • Pan L, Penney J, Tsai L-H. Chromatin regulation of DNA damage repair and genome integrity in the central nervous system. Mol Biol. 2014 Oct 9; doi: 10.1016/j.jmb.2014.08.001. PMID: 25128619.
  • Qiu, H. et al. ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects (2014). J Clin Invest 124, 981–999.
  • Dobbin, M.M., Madabhushi, R., Pan, L., Chen, Y., Kim, D., Gao, J., Ahanonu, B., Pao, P-C., Qiu, Y., Zhao, Y., Tsai, L-H. SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons (2013). Nat. Neurosci. 16, 1008–15.
  • Wang, W.Y., Pan, L., Su, S.C., Quinn, E.J., Sasaki, M., Jiminez, J.C., Mackenzie, I.R., Huang, E.J., Tsai, L-H. Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons (2013). Nat. Neurosci. 16, 1383–1391.
  • Crimins, J.L., Rocher, A.B., Peters, A., Shultz, P., Lewis, J., Luebke, J.I. Homeostatic responses by surviving cortical pyramidal cells in neurodegenerative tauopathy (2011). Acta Neuropathol. 122(5):551-64.
  • Huttlin, E.L., Jedrychowski, M.P., Elias, J.E., Goswami, T., Rad, R., Beausoleil, S.A., Villén, J., Haas, W., Sowa, M.E., Gygi, S.P. A tissue-specific atlas of mouse protein phosphorylation and expression (2010). Cell 143, 1174–1189.
  • Flavell, S. W. & Greenberg, M. E. Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system (2008). Annu. Rev. Neurosci. 31, 563–590.
  • Kim, D., Frank, C., Dobbin, M., Tsunemoto, R., Wu, D., Peng, P., Guan, J., Lee, B-H., Moy, L., Gusti, P., Broodie, N., Mazitschek, R., Delalle, I., Haggarty, S., Neve, R., Lu, Y., Tsai, L-H. Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity (2008). Neuron 60, 803–817.
  • Lu, T., Pan, Y., Kao, S.Y., Li, C., Kohane, I., Chan, J., Yankner, B.A. Gene regulation and DNA damage in the ageing human brain (2004). Nature, 429(6994):883-91.